AI Article Synopsis
- Basal ganglia strokes lead to functional deficits in patients, particularly affecting procedural learning and the ability to acquire new motor skills.
- In a study using C57Bl/6J mice after a 30-minute right MCAO stroke, researchers tested their sensorimotor abilities and found that the stroke impaired performance in certain tests and hindered their capacity to learn a simple motor sequence.
- The difficulty in learning motor sequences was attributed to challenges in organizing actions into coherent sequences, while basic motivations and lever-pressing abilities remained intact, suggesting that evaluating motor learning in stroke models could enhance their relevance for human applications.
Article Abstract
Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a murine model of stroke (30min right MCAO), we submitted C57Bl/6J mice to various sensorimotor tests, then to an operant procedure (Serial Order Learning) specifically assessing the ability to learn a simple motor sequence. Results showed that MCAO affected the performance in some of the sensorimotor tests (accelerated rotating rod and amphetamine rotation test) and the way animals learned a motor sequence. The later finding seems to be caused by difficulties regarding the chunking of operant actions into a coherent motor sequence; the appeal for food rewards and ability to press levers appeared unaffected by MCAO. We conclude that assessment of motor learning in rodent models of stroke might improve the translational value of such models.
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| http://dx.doi.org/10.1016/j.bbr.2016.03.032 | DOI Listing |
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