AI Article Synopsis

  • The study investigates a unique subgroup of ALS patients who can still communicate after long-term mechanical ventilation via tracheostomy.
  • Three patients were analyzed, each with a long survival duration and slow disease progression, while showing significant degeneration of both upper and lower motor neurons.
  • The findings indicate that this subgroup may have distinct pathology, lacking typical ALS hallmarks such as certain protein inclusions, suggesting different disease characteristics.

Article Abstract

Objective: To clarify the position in the amyotrophic lateral sclerosis (ALS) spectrum, of a subgroup of patients who maintained the ability to communicate after long-term mechanical ventilation (LTMV) by tracheostomy.

Methods: We undertook a clinicopathological investigation of sporadic ALS in three patients who maintained the ability to communicate after approximately 30-year survival on LTMV by tracheostomy.

Results: The age of onset and duration of disease was 48 years and 31 years in patient 1, 55 years and 29 years in patient 2, and 31 years and 33 years in patient 3, respectively. Each patient displayed slow disease progression. In all patients, both upper and lower motor neurons were markedly degenerated, while other neuronal systems and the brainstem tegmentum were spared. A few normal-looking motor neurons remained in the anterior horn of the spinal cord. There were no TAR DNA-binding protein 43-immunoreactive inclusions in the lower motor neurons in any patient and only occasional inclusions in the cerebral cortex of one patient.

Conclusion: The clinicopathological findings of these three patients suggest that there is a distinct subgroup of ALS patients characterized by the above-mentioned features.

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Source
http://dx.doi.org/10.1016/j.jns.2016.02.068DOI Listing

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