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Effects of a nighttime melatonin ingestion on dynamic postural balance and muscle strength the following morning in people living with multiple sclerosis: A preliminary study.
Clin Neurol Neurosurg
March 2024
LINP2, UFR STAPS, University of Paris Nanterre, Nanterre, France; Research Laboratory, Molecular bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Tunisia.
Background: Decreased endogenous melatonin concentrations in people with multiple sclerosis (PwMS) are associated with fatigue and pain that impair postural balance and muscle strength. Melatonin ingestion had analgesic and anti-fatigue effects. However, the acute effect of exogenous melatonin on dynamic postural stability and muscle strength has not been studied yet in PwMS.
View Article and Find Full Text PDFMelatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.
J Pineal Res
January 2021
Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang, China.
Article Synopsis
- Melatonin shows promise in reducing diabetic cardiomyopathy (DCM) by improving mitochondrial quality control, though the exact mechanisms need further exploration.
- In a study using diabetic rats, prolonged melatonin treatment increased SIRT6 and AMPK-PGC-1α-AKT signaling, leading to reduced mitochondrial damage and better heart function.
- Blocking SIRT6 or melatonin receptors negated the benefits of melatonin, indicating that the SIRT6-AMPK-PGC-1α-AKT pathway is crucial for its cardioprotective effects in the context of diabetes.
Melatonin-induced phase and dose responses in a diurnal mammal, .
Chronobiol Int
May 2020
Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Melatonin, an essential pineal hormone, acts as a marker of the circadian clock that regulates biological rhythms in animals. The effects of exogenous melatonin on the circadian system of nocturnal rodents have been extensively studied; however, there is a paucity of studies on the phase-resetting characteristics of melatonin in diurnal rodents. We studied the phase shifting effects of exogenous melatonin as a single melatonin injection (1 mg/kg) at various phases of the circadian cycle on the circadian locomotor activity rhythm in the palm squirrel, .
View Article and Find Full Text PDFMelatonin Effects on EEG Activity During Sleep Onset in Mild-to-Moderate Alzheimer's Disease: A Pilot Study.
J Alzheimers Dis Rep
March 2018
Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Subdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología, CDMX, México.
There is evidence demonstrating that 5-mg of fast-release melatonin significantly reduces nocturnal sleep onset in patients with mild-to-moderate Alzheimer's disease (AD). However, the physiological mechanism that could promote sleep installation by melatonin in patients with AD is still poorly understood. The present pilot study was designed to analyze the effects of melatonin on cortical activity during the sleep onset period (SOP) in eight mild-to-moderate AD patients treated with 5-mg of fast-release melatonin.
View Article and Find Full Text PDFMelatonin-Induced Nocturnal Vasodilatation Contributes to Skin Regeneration-Reply.
JAMA Pediatr
June 2016
Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan5Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan6Department of Medical Research, National Taiwan University Hospital.
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