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Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis. | LitMetric

Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis.

J Clin Med

21st Century Oncology, 4571 Colonial Blvd., Suite 210, Fort Myers, FL 33966, USA.

Published: March 2016

AI Article Synopsis

Article Abstract

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810109PMC
http://dx.doi.org/10.3390/jcm5030038DOI Listing

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