AI Article Synopsis
- The study examined how fibrous encapsulation impacts the electrochemical properties of porous titanium nitride electrodes in a living organism (in vivo).
- Electrochemical impedance spectroscopy (EIS) was used to monitor inflammation and healing, revealing that the encapsulation lasted 3-4 weeks, during which voltage transients (VTs) increased and charge storage capacity (CSC) decreased.
- The findings suggest that the changes in VTs and CSC are linked to the healing process, and that traditional methods may underestimate the limits of charge injection during encapsulation.
Article Abstract
The aim of this study was to investigate how the electrochemical properties of porous titanium nitride stimulation electrode are affected by fibrous encapsulation in vivo. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry and voltage transient (VT) measurements were performed in vivo and in phosphate buffered saline, where the encapsulation process is absent. EIS was used as a non-invasive measurement to follow the inflammation, healing and encapsulation process. EIS showed that the healing and encapsulation process lasted 3-4 weeks. The VTs increased during the first 3-4 weeks, after which they stabilized. The charge storage capacity (CSC) decreased most during the first 3-4 weeks. The increasing VTs and decreasing CSC during the first 3-4 weeks after implantation of the in vivo electrodes seem related to healing and fibrous encapsulation. It is suggested that the charge injection pathway during the encapsulation process changes, which implies that charge injection limits are underestimated with conventional methods.
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| http://dx.doi.org/10.1016/j.medengphy.2016.02.010 | DOI Listing |
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