Background: Despite numerous clinical trials no efficacious medications for methamphetamine (MA) have been identified. Neuroinflammation, which has a role in MA-related reward and neurodegeneration, is a novel MA pharmacotherapy target. Ibudilast inhibits activation of microglia and pro-inflammatory cytokines and has reduced MA self-administration in preclinical research. This study examined whether ibudilast would reduce subjective effects of MA in humans.
Methods: Adult, non-treatment seeking, MA-dependent volunteers (N=11) received oral placebo, moderate ibudilast (40 mg), and high-dose ibudilast (100mg) via twice-daily dosing for 7 days each in an inpatient setting. Following infusions of saline, MA 15 mg, and MA 30 mg participants rated 12 subjective drug effects on a visual analog scale (VAS).
Results: As demonstrated by statistically-significant ibudilast × MA condition interactions (p<.05), ibudilast reduced several MA-related subjective effects including High, Effect (i.e., any drug effect), Good, Stimulated and Like. The ibudilast-related reductions were most pronounced in the MA 30 mg infusions, with ibudilast 100mg significantly reducing Effect (97.5% CI [-12.54, -2.27]), High (97.5% CI [-12.01, -1.65]), and Good (97.5% CI [-11.20, -0.21]), compared to placebo.
Conclusions: Ibudilast appeared to reduce reward-related subjective effects of MA in this early-stage study, possibly due to altering the processes of neuroinflammation involved in MA reward. Given this novel mechanism of action and the absence of an efficacious medication for MA dependence, ibudilast warrants further study to evaluate its clinical efficacy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349508 | PMC |
| http://dx.doi.org/10.1016/j.drugalcdep.2016.02.036 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Positive affect amplifies integration within episodic memories in the laboratory and the real world.
Learn Mem
January 2025
Department of Psychiatry, Yale University, New Haven, Connecticut 06511, USA
Emotional events hold a privileged place in our memories, differing in accuracy and structure from memories for neutral experiences. Although much work has focused on the pronounced differences in memory for negative experiences, there is growing evidence that positive events may lead to more holistic, or integrated, memories. However, it is unclear whether these affect-driven changes in memory structure, which have been found in highly controlled laboratory environments, extend to real-world episodic memories.
View Article and Find Full Text PDFInteractive segmentation for accurately isolating metastatic lesions from low-resolution, large-size bone scintigrams.
Phys Med Biol
January 2025
Charles Sturt University, Albury-Wodonga, NSW, Albury, New South Wales, 2640, AUSTRALIA.
Bone is a common site for the metastasis of malignant tumors, and Single Photon Emission Computed Tomography (SPECT) is widely used to detect these metastases. Accurate delineation of metastatic bone lesions in SPECT images is essential for developing treatment plans. However, current clinical practices rely on manual delineation by physicians, which is prone to variability and subjective interpretation.
View Article and Find Full Text PDFSingle and combined effects of environmental heat stress and physical exercise on thermoregulation, executive function, and cerebral oxygenation.
J Therm Biol
January 2025
School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China. Electronic address:
This study investigated the single and combined effects of environmental heat stress and physical exercise on executive function (EF) performance, prefrontal cortex oxygenation, thermoregulatory responses and subjective perceptions. Sixteen subjects participated in four experimental sessions: two under moderate environmental conditions (23 °C), with and without physical exercise (R23, E23), and two under hot environmental conditions (35 °C), with and without physical exercise (R35, E35). In each session, participants completed EF tasks before and after 1 h of passive rest or 45 min of moderate-intensity cycling followed by 15 min of rest.
View Article and Find Full Text PDFMultimodal Pain Recognition in Postoperative Patients: Machine Learning Approach.
JMIR Form Res
January 2025
Department of Computer Science, University of California, Irvine, Irvine, CA, United States.
Background: Acute pain management is critical in postoperative care, especially in vulnerable patient populations that may be unable to self-report pain levels effectively. Current methods of pain assessment often rely on subjective patient reports or behavioral pain observation tools, which can lead to inconsistencies in pain management. Multimodal pain assessment, integrating physiological and behavioral data, presents an opportunity to create more objective and accurate pain measurement systems.
View Article and Find Full Text PDFMass Casualty Incident Training in Immersive Virtual Reality: Quasi-Experimental Evaluation of Multimethod Performance Indicators.
J Med Internet Res
January 2025
Psychological Institute and Network Aging Research, Heidelberg University, Heidelberg, Germany.
Background: Immersive virtual reality (iVR) has emerged as a training method to prepare medical first responders (MFRs) for mass casualty incidents (MCIs) and disasters in a resource-efficient, flexible, and safe manner. However, systematic evaluations and validations of potential performance indicators for virtual MCI training are still lacking.
Objective: This study aimed to investigate whether different performance indicators based on visual attention, triage performance, and information transmission can be effectively extended to MCI training in iVR by testing if they can discriminate between different levels of expertise.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!