AI Article Synopsis
- β-Defensin-1 is an antimicrobial peptide linked to lung immune defense, encoded by the DEFB1 gene.
- A study examined three DEFB1 gene polymorphisms in 92 tuberculosis patients and 286 healthy individuals from Northeast Brazil, finding no significant association with the disease.
- However, the study's low statistical power (0.16 to 0.50) due to the small sample size suggests that the results may not be definitive.
Article Abstract
β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874611 | PMC |
| http://dx.doi.org/10.1016/j.bjm.2015.09.001 | DOI Listing |
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