Rapid Assembly of Heterogeneous 3D Cell Microenvironments in a Microgel Array.

Adv Mater

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China.

Published: May 2016

AI Article Synopsis

  • Heterogeneous 3D cell microenvironment arrays are created using surface-wettability-guided assembly and microdroplet operations, allowing for rapid construction.
  • This method allows for fine-tuned control over the shapes, sizes, chemical concentrations, cell density, and 3D arrangement of different components.
  • It offers a budget-friendly option to support growing needs in areas like stem cell research, tissue engineering, and drug screening.

Article Abstract

Heterogeneous 3D cell microenvironment arrays are rapidly assembled by combining surface-wettability-guided assembly and microdroplet-array-based operations. This approach enables precise control over individual shapes, sizes, chemical concentrations, cell density, and 3D spatial distribution of multiple components. This technique provides a cost-effective solution to meet the increasing demand of stem cell research, tissue engineering, and drug screening.

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Source
http://dx.doi.org/10.1002/adma.201600247DOI Listing

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