Cancer cells in hypoxia usually make adaptive changes in cellular metabolism, such as altered autophagy. This might be a cause of enhanced radioresistance in some types of cancer. In this study, we investigated hypoxia-responsive miRNAs in two prostate cancer cell lines (DU145 and PC3). This study firstly reported that hypoxia induces further downregulation of miR-124 and miR-144, which might be a result of impaired dicer expression. These two miRNAs can simultaneously target 3'UTR of PIM1. Functional study showed that miR-124 or miR-144 overexpression can inhibit hypoxia-induced autophagy and enhance radiosensitivity at least via downregulating PIM1. Therefore, hypoxia induced miR-124 and miR-144 downregulation may contribute to a prosurvival mechanism of prostate cancer cells to hypoxia and irradiation at least through attenuated suppressing of PIM1. This finding presents a potential therapeutic target for prostate cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924376 | PMC |
| http://dx.doi.org/10.1002/cam4.664 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
MicroRNA Profiling as a Predictive Indicator for Time to First Treatment in Chronic Lymphocytic Leukemia: Insights from the O-CLL1 Prospective Study.
Noncoding RNA
August 2024
Molecular Pathology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
A "watch and wait" strategy, delaying treatment until active disease manifests, is adopted for most CLL cases; however, prognostic models incorporating biomarkers have shown to be useful to predict treatment requirement. In our prospective O-CLL1 study including 224 patients, we investigated the predictive role of 513 microRNAs (miRNAs) on time to first treatment (TTFT). In the context of this study, six well-established variables (i.
View Article and Find Full Text PDFIdentifying the differentially expressed peripheral blood microRNAs in psychiatric disorders: a systematic review and meta-analysis.
Front Psychiatry
May 2024
Molecular Biology Laboratory, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- A study investigated the role of microRNAs (miRNAs) in schizophrenia, major depression disorder, and bipolar disorder by analyzing their expression levels in peripheral blood samples.
- Researchers reviewed literature up to September 2023, finding 30 miRNAs relevant to these psychiatric disorders, with notable upregulation of specific miRNAs in schizophrenia and major depression but no differences in bipolar disorder.
- The findings suggest that miR-132-3p and miR-34a-5p are potential biomarkers for diagnosing schizophrenia and major depression, highlighting their importance in understanding these conditions.
Evaluation of a Set of miRNAs in 26 Cases of Fatal Traumatic Brain Injuries.
Int J Mol Sci
June 2023
DSM-Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy.
In forensic medicine, identifying novel biomarkers for use as diagnostic tools to ascertain causes of death is challenging because of sample degradation. To that aim, a cohort ( = 26) of fatal traumatic brain injuries (TBIs) were tested for three candidate miRNAs (namely, miR-124-3p, miR-138-5p, and miR144-3p). For each case, three FFPE specimens (coup area (CA), contrecoup area (CCA), and the corpus callosum (CC)) were investigated, whereas the FFPE brain tissues of 45 subjects (deceased due to acute cardiovascular events) were used as controls.
View Article and Find Full Text PDFStructural and Pharmacological Network Focused on MiRNAs Involved in Rheumatoid Arthritis: A Systematic Review.
Curr Mol Med
May 2024
Laboratorio de Microscopia Electrónica, Instituto Nacional de Rehabilitación, Mexico City, 14389, Mexico.
Background: Rheumatoid Arthritis (RA) is a chronic autoimmune disease that has a prevalence of over one percent of the world population, causing substantial pain, joint deformity, and functional disability in patients. The identification and measurement of miRNAs are relatively easy to perform. Future studies will corroborate if miRNAs can fulfill their roles as biomarkers with either predictive or diagnostic evaluation of treatment potential and provide actual clinical utility.
View Article and Find Full Text PDFMicroRNA miR-124-3p suppresses proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma via ARRDC1 (arrestin domain containing 1).
Bioengineered
April 2022
Department of Laboratory Medicine, Yantai Mountain Hospital, Yantai, Shandong, China.
Hepatocellular carcinoma (HCC) is responsible for high morbidity and mortality worldwide. Increasing evidence suggests that microRNAs intensively participate in HCC development and progression. In the current study, we aimed to explore the impact of miR-124-3p in the proliferation and epithelial-mesenchymal transition (EMT) of HCC.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!