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Growth of microbes in competitive lifestyles promotes increased ARGs in soil microbiota: insights based on genetic traits.
Microbiome
January 2025
Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
Background: The widespread selective pressure of antibiotics in the environment has led to the propagation of antibiotic resistance genes (ARGs). However, the mechanisms by which microbes balance population growth with the enrichment of ARGs remain poorly understood. To address this, we employed microcosm cultivation at different antibiotic (i.
View Article and Find Full Text PDFAstragaloside IV Relieves Central Sensitization by Regulating Astrocytic ROS/NF-κB Nuclear Translocation Signaling in Chronic Migraine Male Rats.
Phytother Res
January 2025
Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chronic migraine (CM) is a disabling neurological disease. Astragaloside IV (AS-IV), a natural product derived from Astragalus membranaceus, shows great potential in treating chronic pain by relieving inflammation and oxidative stress. This study aimed to investigate the effects and mechanisms of action of AS-IV on CM.
View Article and Find Full Text PDFDisposal practices, risk perceptions, and quantification of potential active pharmaceutical ingredients (APIs) from used human medicine in Upper Citarum River Basin.
Int J Environ Health Res
January 2025
Research Center for Limnology and Water Resources, National Research and Innovation Agency, Bogor, Indonesia.
This paper highlights potential active pharmaceutical ingredients (APIs) generations from improper disposal of medicines and captures the perceptions of key stakeholders - households and pharmaceutical actors in Upper Citarum River Basin (UCRB). Most pharmaceutical waste is disposed of with household waste, suggesting landfills are the most significant APIs contamination sources. We highlight the complex relationship between knowledge, risk perception, and behavioural intentions, stressing the relevance of risk perception as a mediator when studying how knowledge affects behaviour.
View Article and Find Full Text PDFTowards measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime.
Biophys Rep (N Y)
January 2025
UCLA-DOE Institute for Genomics and Proteomics, Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA,; Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA,; Department of Physiology, University of California at Los Angeles, Los Angeles, CA 90095, USA,; California Nano Systems Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA,; Department of Physics, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel.
Membrane potential (MP) changes can provide a simple readout of bacterial functional and metabolic state or stress levels. While several optical methods exist for measuring fast changes in MP in excitable cells, there is a dearth of such methods for absolute and precise measurements of steady-state membrane potentials (MPs) in bacterial cells. Conventional electrode-based methods for the measurement of MP are not suitable for calibrating optical methods in small bacterial cells.
View Article and Find Full Text PDFEffects of a L. Extract and Rosmarinic Acid in Improving Streptozotocin-Induced Aortic Tissue Damages in Rats.
Nutrients
December 2024
Department of Pharmacognosy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania.
Background/aim: L. () is an aromatic medicinal species with important nutraceutical potential, having rosmarinic acid (RA) as one of its main metabolites. The present study aims to evaluate the effects of an extract obtained from the leaves of this species and of its main metabolite in improving the streptozotocin-induced damage of hearts and aorta of diabetic rats.
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