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Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men. | LitMetric

AI Article Synopsis

  • This study investigated the relationship between serum 25-hydroxyvitamin D (s-25(OH)D) levels and total mortality among men, specifically focusing on those with and without prostate cancer.
  • Results showed that lower s-25(OH)D levels (<50 nmol/l) were linked to an increased risk of total mortality in men with prostate cancer, implying an inverse relationship.
  • However, no significant links were found between s-25(OH)D and cause-specific deaths, highlighting a unique pattern where low vitamin D levels correlate with higher mortality despite higher levels being associated with prostate cancer risk.

Article Abstract

Objective: A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality.

Methods: Men participating in population based health screenings during 1981-1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression.

Results: In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05-1.50), s-25(OH)D <50 nmol/l versus s-25(OH)D ≥ 50 nmol/l). The corresponding figure among controls (n = 2147) was HR = 1.15 (95% CI 0.88-1.50) and in the total study population HR = 1.19 (95% CI 1.03-1.38). For cause-specific deaths, we found no significant associations.

Conclusions: In this study population, s-25(OH)D was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high s-25(OH)D was associated with increased risk of prostate cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795600PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151441PLOS

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