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Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae.
NPJ Vaccines
January 2025
Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Neisseria gonorrhoeae is an on-going public health problem due in part to the lack of success with efforts to develop an efficacious vaccine to prevent this sexually transmitted infection. The gonococcal transferrin binding protein B (TbpB) is an attractive candidate vaccine antigen. However, it exhibits high levels of antigenic variability, posing a significant obstacle in evoking a broadly protective immune response.
View Article and Find Full Text PDFInfluences of school climate on emotional health and academic achievement of school-going adolescents in India: a systematic review.
BMC Public Health
January 2025
Department of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, India.
Background: As students spend most of their time in school, a supportive school environment is essential for adolescents' personal growth, effective learning, and well-being. Students actively participate in learning when they feel supported, respected, and connected to their school environment. An unhealthy school climate might significantly influence health-related and educational outcomes during adolescence.
View Article and Find Full Text PDFVoluntary Medical Male Circumcision's (VMMC) strategy for HIV prevention in Sub-Saharan Africa, prevalence, risks, costs, benefits and best practice: A scoping review study protocol of progress and unfolding insights.
PLoS One
December 2024
Department of General Nursing Science, Faculty of Health Sciences, University of Eswatini, Mbabane, Eswatini.
Campaigns to scale up Voluntary Medical Male Circumcision (VMMC) for the prevention of HIV transmission has been going on for years in selected Southern African countries, following recommendations from the World Health Organisations. Despite significant strides made in the initiative and its proven benefits, controversies surrounding the strategy have never ceased, and its future remains uncertain especially as some countries near their initial targets. Over the years, as the campaigns unfolded, a lot of insights have been generated in favour of continuing the VMMC campaigns, although some insights portray the impression that the strategy is not worthy of the risks and effort required, or that enough has been done, as the targets have now been achieved.
View Article and Find Full Text PDFBrain functional imaging contributions in osteoarthritis-related pain: A viewpoint.
Osteoarthr Cartil Open
March 2025
Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Objective: Neuroimaging investigations are critical to provide a more direct assessment of brain disturbances associated with osteoarthritis (OA)-related pain, and to better understand its pathophysiology to develop new treatment strategies. This viewpoint aims to summarize the importance of the brain in OA pain.
Method: A European working group on pain in osteoarthritis GO-PAIN (Going Inside Osteoarthritis-related Pain Phenotyping) has been created to work on a global assessment of the OA-related pain.
Prior information guided deep-learning model for tumor bed segmentation in breast cancer radiotherapy.
BMC Med Imaging
November 2024
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Article Synopsis
- Identifying the tumor bed (TB) after surgical removal of a tumor is essential for effective radiotherapy planning, but segmenting it from surrounding tissues using CT images poses significant challenges.
- A new deep learning model enhances the delineation of TB by using prior tumor location information from both pre-operative and post-operative CT scans, improving accuracy in identifying treatment volumes.
- The model demonstrated a significant improvement in segmenting TB, achieving a higher dice similarity coefficient compared to traditional methods and models without prior information, indicating better performance in clinical applications.
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