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Distributions of autofluorescence after compensation: Be panglossian, fret not.
Cytometry A
April 2016
Flow Cytometry Core and ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland.
In this technical note, I describe an in silico model of multiparameter fluorescence measurements that takes into account intrinsic cellular autofluorescence and stained dye fluorescence distributions, fluorescence spectrum spillovers, and photon counting statistics. Using this model, it is easy to manipulate spectral variables as well as error terms to understand the impact of each on the distributions of estimated cell-associated dyes (e.g.
View Article and Find Full Text PDF[ENCODE apophenia or a panglossian analysis of the human genome].
Med Sci (Paris)
September 2015
Laboratoire Évolution, génomes, comportement, écologie, CNRS université Paris-Sud UMR 9191, IRD UMR 247, Avenue de la Terrasse, bâtiment 13, boîte postale 1, 91198 Gif-sur-Yvette, France - Université Paris-Diderot, Sorbonne Paris-Cité, Paris, France.
In September 2012, a batch of more than 30 articles presenting the results of the ENCODE (Encyclopaedia of DNA Elements) project was released. Many of these articles appeared in Nature and Science, the two most prestigious interdisciplinary scientific journals. Since that time, hundreds of other articles dedicated to the further analyses of the Encode data have been published.
View Article and Find Full Text PDFIn this issue of Blood, Levine et al present an intriguing analysis highlighting the potential clinical impact of Paneth cell loss in gastrointestinal (GI) acute graft-versus-host disease (GVHD).
View Article and Find Full Text PDFOur analysis of the interviews with a sample of the California public about a range of their attitudes toward technology shows that a modification of our understanding of the collective state of mind on this subject is in order. The current assessment of the public as largely, and somewhat vacantly, enamored with science and technology does not hold. Nor does a picture of a public generally hostile and alienated by technology.
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