The brutal treatment handed out to residents at Winterbourne View hospital in Bristol - shown on the BBC's Panorama programme in 2011 - shocked and appalled the nation.
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| http://dx.doi.org/10.7748/ns2013.04.27.31.26.p10911 | DOI Listing |
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Antibiotic exposure enriches streptococci carrying resistance genes in periodontitis plaque biofilms.
PeerJ
January 2025
Department of Dental Materials, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Background: Periodontitis is not always satisfactorily treated with conventional scaling and root planing, and adjunctive use of antibiotics is required in clinical practice. Therefore, it is important for clinicians to understand the diversity and the antibiotic resistance of subgingival microbiota when exposed to different antibiotics.
Materials And Methods: In this study, subgingival plaques were collected from 10 periodontitis patients and 11 periodontally healthy volunteers, and their microbiota response to selective pressure of four antibiotics (amoxicillin, metronidazole, clindamycin, and tetracycline) were evaluated through 16S rRNA gene amplicon and metagenomic sequencing analysis.
Sex, ethnicity and language differences in statin prescribing in community health center patients.
Am J Prev Cardiol
December 2024
Department of Family Medicine, Oregon Health & Science University, USA.
Background: Statins have been shown to reduce atherosclerotic cardiovascular disease (ASCVD). In the United States, statins are underutilized, and the literature suggests women and Latine individuals received even fewer prescriptions than men even when eligible. No study has shown how statins are prescribed when looking at language, ethnicity, and considering sex.
View Article and Find Full Text PDFLifetime stressors relate to invisible symptoms of multiple sclerosis.
Explor Neuroprotective Ther
April 2024
School of Nursing, University of Michigan, Ann Arbor, MI 48109, USA.
Aim: Childhood stressors can increase adult stress perception and may accumulate over the lifespan to impact symptoms of multiple sclerosis (MS). Growing evidence links childhood stressors (e.g.
View Article and Find Full Text PDFDevelopment and validation of a prediction model for coronary heart disease risk in depressed patients aged 20 years and older using machine learning algorithms.
Front Cardiovasc Med
January 2025
Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, Fujian, China.
Background: Depression is being increasingly acknowledged as an important risk factor contributing to coronary heart disease (CHD). Currently, there is no predictive model specifically designed to evaluate the risk of coronary heart disease among individuals with depression. We aim to develop a machine learning (ML) model that will analyze risk factors and forecast the probability of coronary heart disease in individuals suffering from depression.
View Article and Find Full Text PDFEstimating health state utilities for aromatic L-amino acid decarboxylase deficiency (AADCd) in the United States.
Health Qual Life Outcomes
January 2025
PTC Therapeutics Inc, 500 Warren Corporate Center Drive, Warren, N.J, 07059, USA.
Background: AADCd is a rare neurometabolic disorder presenting in infancy. Children with AADCd have motor dysfunction and development delays that result in the need for lifelong care; quality of life is greatly impacted. Current characterizations of health-related quality of life and associated health state utilities (HSUs) may be underestimated in AADCd.
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