AI Article Synopsis
- * Researchers conducted transcriptome sequencing on various stem cell types from both healthy and CML-affected mice to explore this accumulation.
- * The findings showed that the dipeptide transporter SLC15A2 is elevated specifically in CML stem cells, suggesting it plays a key role in the accumulation process.
Article Abstract
Dipeptide species are accumulated in the chronic myelogenous leukemia (CML) stem cells [1]. To investigate the molecular mechanisms of the accumulation of dipeptide species in CML stem cells, we performed transcriptome sequencing of long-term stem cells, short-term stem cells, progenitor cells from healthy control and CML-affected mice (GSE70031). The transcriptome data revealed that the expression of a dipeptide transporter (solute carrier family 15, member 2 (SLC15A2)) was elevated only in the CML stem cells. This result indicates that dipeptide species accumulates in CML stem cells through a dipeptide transporter SLC15A2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778595 | PMC |
| http://dx.doi.org/10.1016/j.gdata.2015.11.017 | DOI Listing |
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