AI Article Synopsis
- * Ile-Tyr was found to significantly increase dopamine and its metabolites, while Ser-Tyr boosted noradrenaline turnover, and Tyr-Pro suppressed dopamine turnover.
- * The results indicate that these dipeptides have unique impacts on catecholamine metabolism when ingested orally, highlighting their potential physiological roles in the brain.
Article Abstract
Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone. In comparison, administration of Ser-Tyr induced significantly increasing noradrenaline turnover, while Tyr-Pro administration suppressed dopamine turnover. Therefore, oral administration of Ile-Tyr, Ser-Tyr, and Tyr-Pro differentially affected metabolism of dopamine and noradrenaline. These observations strongly suggest that Tyr-containing dipeptides exert distinct effects on catecholamine metabolism in the brainstem when ingested orally.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766323 | PMC |
| http://dx.doi.org/10.1155/2016/6020786 | DOI Listing |
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