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Costimulation blockade: the next generation.
Curr Opin Organ Transplant
January 2025
Division of Nephrology, Virginia Commonwealth University, Richmond, Virginia, USA.
Purpose Of The Review: Calcineurin inhibitors (CNIs) are central to immunosuppression in kidney transplantation (KT), improving short-term outcomes but falling short in enhancing long-term outcomes due to cardiovascular, metabolic, and renal complications. Belatacept, an FDA-approved costimulation blocker, offers a less toxic alternative to CNIs but is limited by its intravenous administration and reduced efficacy in high-immunological-risk patients.
Recent Findings: Emerging therapies target more specific pathways to improve efficacy and accessibility.
A targeted and synergetic nano-delivery system against infection for promoting wound healing.
Mater Today Bio
April 2025
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan Province, China.
Purpose: infection is the most common pathogen in burn wound infections, causing delayed wound healing and progression to chronic wounds. Therefore, there is an urgent need to develop antimicrobial agents that can promote wound healing for effectively treating infected wounds.
Patients And Methods: Using magnetic stirring and ultrasound to synthesize Apt-pM@UCNPmSiO-Cur-CAZ.
Chemical composition and insecticidal efficacy of two animals' horn and hoof crude extracts against lesser grains borer, (F.) [Coleoptera: Bostrichidae].
Heliyon
January 2025
Department of Animal Production and Health, School of Agriculture and Agricultural Technology, Federal University of Technology,P. M. B. 704, Akure, Ondo State, Nigeria.
This research evaluated the profiling of bioactive compounds and insecticidal activities of the crude extracts of horns and hoofs of cow and goat against on wheat grains. Different concentrations (0.1, 0.
View Article and Find Full Text PDFMonitoring and management of adverse effects associated with trastuzumab deruxtecan: a UAE-specific consensus.
Front Oncol
January 2025
Department of Oncology, Tawam Hospital, Al Ain, United Arab Emirates.
Breast cancer is the most frequently diagnosed cancer in the UAE and a leading cause of cancer-related mortality. Although early diagnosis contributes to favorable prognoses, novel treatment modalities like antibody-drug conjugates (ADCs) have significantly broadened the therapeutic landscape for patients in metastatic settings. The recognition of "HER2-low" expression as a targetable category has caused a paradigm shift in the management of breast cancer.
View Article and Find Full Text PDFPeptide-based amyloid-beta aggregation inhibitors.
RSC Med Chem
December 2024
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research Sector 67, S. A. S. Nagar Punjab 160062 India
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Aggregation of amyloid-β (Aβ) peptide leads to the formation of toxic amyloid fibrils and is associated with cognitive dysfunction and memory loss in Alzheimer's disease (AD). Designing molecules that inhibit amyloid aggregation seems to be a rational approach to AD drug development.
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