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[Protective effect of K12 against infection in mice].
Nan Fang Yi Ke Da Xue Xue Bao
December 2024
Department of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Objectives: To investigate the protective effect of the probiotic bacterium K12 (K12) against (Mp) infection in mice.
Methods: Forty male BALB/c mice were randomized into normal control group, K12 treatment group, Mp infection group, and K12 pretreatment prior to Mp infection group. The probiotic K12 was administered daily by gavage for 14 days before Mp infection induced by intranasal instillation of Mp.
Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice.
Biomed Pharmacother
December 2024
Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan; Division of Medical Oncology, Department of Medicine, Showa University Graduate School of Medicine, Tokyo, Japan. Electronic address:
Gut bacteria play pivotal roles in the antitumor effects of immune checkpoint inhibitors (ICIs). However, antimicrobial therapy, often necessary for infections in cancer patients, can reduce the efficacy of ICIs. The potential of probiotics to restore ICI efficacy remains uncertain.
View Article and Find Full Text PDFMachine learning-enhanced assessment of potential probiotics from healthy calves for the treatment of neonatal calf diarrhea.
Front Microbiol
December 2024
Department of Animal Sciences, University of Florida, Gainesville, FL, United States.
Neonatal calf diarrhea (NCD) remains a significant contributor to calf mortality within the first 3 weeks of life, prompting widespread antibiotic use with associated concerns about antimicrobial resistance and disruption of the calf gut microbiota. Recent research exploring NCD treatments targeting gut microbiota dysbiosis has highlighted probiotic supplementation as a promising and safe strategy for gut homeostasis. However, varying treatment outcomes across studies suggest the need for efficient treatment options.
View Article and Find Full Text PDFProbiotic: A Gut Microbiota-Based Therapeutic Approaches for the Treatment of Parkinson's Disease.
Curr Rev Clin Exp Pharmacol
December 2024
School of Pharmaceutical Sciences, Siksha O Anusandhan deemed to be University, Bhubaneswar, India.
Article Synopsis
- The number of people diagnosed with Parkinson's disease (PD) may surpass 10 million globally by 2040, raising concerns about its unclear causes.
- Recent studies have explored the gut-brain axis, suggesting that gut bacteria and gut dysbiosis may influence PD by contributing to inflammation and accelerating nerve damage.
- Research also indicates that probiotics could potentially treat PD by restoring gut balance, increasing brain dopamine levels, and reducing neurodegeneration through mechanisms involving oxidative stress and α-synuclein aggregation.
Protective effects of Sulforaphene on kidney damage and gut dysbiosis in high-fat diet plus streptozotocin-induced diabetic mice.
Food Chem
December 2024
State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
Diabetic nephropathy (DN) is one of the most serious and prevalent complications associated with diabetes. Consequently, antidiabetic drugs or foods potentially protecting the kidneys are of significant therapeutic value. Sulforaphene (SFE) is a natural isothiocyanate derived from radish seeds, known for its anti-inflammatory and antioxidant properties.
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