Misoprostol is a well known abortifacient. It can cause teratogenicity like Mobius sequence and terminal transverse limb defects. We report a rare case of proximal focal femoral deficiency with fibular hemimelia in a woman who had attempted abortion with self-administered misoprostol and later continued the pregnancy. Though the absolute risk of congenital malformations with its use is low ∼1%, this should be clearly communicated to the women requesting abortion to help them make fully informed reproductive health decisions.
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http://dx.doi.org/10.3109/01443615.2016.1157152 | DOI Listing |
J Am Acad Orthop Surg
December 2024
From the Orthopaedic and Rehabilitation Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. (Shahcheraghi and Javid) and Isfahan University of Medical Sciences, Isfahan, Iran (Nemati).
Background: Congenital femoral deficiency (CFD) is a rare condition, often associated with other skeletal anomalies that make the management more difficult. This study aimed to present the risk factors associated with complications in reconstruction of CFD.
Methods: This was a retrospective cohort study on patients with CFD who underwent femoral reconstruction between 2002 and 2022, from a single center.
J Pediatr Orthop
December 2024
Department of Spine Disorders and Pediatric Orthopedics, Poznan University of Medical Sciences, Poznan, Poland.
Background: Management of ankle joint deformity and instability are challenging issues in congenital fibular hemimelia (FH). This study aims to assess how much the SUPERankle procedure improves ankle alignment and provides durable ankle stability in patients with severe FH.
Methods: Seventeen children aged 53.
J Pediatr Orthop B
November 2024
Pediatric Orthopaedics and Reconstruction Group, Department of Orthopaedics and Traumatology, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE) São Paulo, São Paulo, Brazil.
The objective of this study was to analyze the treatment of recurrent valgus knee in fibular hemimelia patients with hemiepiphysiodesis and define associated variables for deformity relapse. Sixteen consecutive patients with fibular hemimelia treated with hemiepiphysiodesis (57 physis) were compared to 21 physis of idiopathic cases, in terms of magnitude, speed, and time of correction. Correction of valgus deformity was successfully achieved in all cases.
View Article and Find Full Text PDFArch Orthop Trauma Surg
September 2024
Dept. of Research, BG Kliniken - Klinikverbund der gesetzlichen Unfallversicherung gGmbH (Hospital Group of the German Social Accident Insurance, Leipziger Pl. 1, 10117, Berlin, Germany.
Introduction: Amongst low- to middle income countries (LMIC), outdated and poorly documented orthopedic interventions may pose patients at risk for complications, serious adverse events (SAE) and unsatisfactory results, contradicting the World Health Organization's (WHO) Safe Surgery mandates. Use cases of conditions managed inadequately in LMIC environments are necessary to increase awareness of stakeholders and overcome deficiencies in collaboration with high-income countries (HIC).
Materials And Methods: Methodological and clinical experts from the BG Kliniken and the Charité, Berlin, Germany, were invited to investigate established processes for musculoskeletal disorders and injuries in Tashkent, Uzbekistan.
J Clin Ultrasound
January 2025
Department of Ultrasound, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Sirenomelia is a rare congenital caudal abnormality. We applied two-dimensional, three-dimensional, and color Doppler ultrasound to diagnose a fetus with sirenomelia at 12 + 6 weeks. The fetus exhibited on ultrasound fused lower limbs, two tibiae in lower legs, no fibulae, knees in retroflexion, pelvic hypoplasia, hypoplasia of the lower lumbar vertebrae and coccyx, bilateral renal agenesis, no bladder, and a single umbilical artery.
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