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A Supramolecular Fluorescent Chemosensor Enabling Specific and Rapid Quantification of Norepinephrine Dynamics.
J Am Chem Soc
January 2025
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China.
Host-guest supramolecular fluorescence probes have garnered significant attention in the detection and sensing of bioactive molecules due to their functionalization potential, adjustable physical properties, and high specificity. However, such probes that reliably, rapidly, and specifically measure neurotransmitter dynamics at the cellular and in vivo level have yet to be reported. Herein, we present a supramolecular fluorescent chemosensor designed for norepinephrine (NE) detection, showing an exceptional response and specificity through host-guest complexation.
View Article and Find Full Text PDFThe role of fear and dopamine-striatal pathways in grooming.
Neuropharmacology
January 2025
School of Psychological Sciences, The University of Haifa, Haifa, Israel; The Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel. Electronic address:
Fear is a fundamental emotion that triggers rapid and automatic behavioral response. Fear is known to suppress reward-seeking behaviors, interrupt previous activities to prioritize defensive responses and lead to rapid switch to defensive reactions. Dopamine (DA) plays a complicated role in the choice and performance of actions and it has a potential interaction of innate actions with the presence of fear.
View Article and Find Full Text PDFAssessing response to stressful emotions: a controlled crossover study using pupillometry.
Porto Biomed J
January 2025
Basic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
Background: Fear and horror induce autonomic protective responses, acting as "survival intelligence." Pupillometry is an innovative method that captures real-time autonomic nervous system reactions to stress.
Objective: To evaluate the feasibility of pupillometry to assess the acute response to a passive real-life stressor-viewing a truthful war scene.
Scarcity mindset facilitates empathy for social pain and prosocial intention: behavioral and neural evidences.
Soc Cogn Affect Neurosci
January 2025
School of Psychology, Shenzhen University, Shenzhen 518060, China.
Empathy for social pain encompasses both affective and cognitive responses to others' emotional reactions following negative social encounters, facilitating an understanding of their suffering and promoting prosocial behaviors. This study examined how a scarcity mindset affects empathy for social pain and prosocial intentions at behavioral and neural levels. Sixty participants were randomly assigned to either the scarcity or abundance mindset group.
View Article and Find Full Text PDFWomen Ridesharing Drivers' Responses to Sexual Violence on the Job: The Role of Confrontation.
J Interpers Violence
January 2025
Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.
One critical area where sexual violence has been underexplored is in the ridesharing industry in the United States, where women drivers frequently must interact with unknown male passengers. Sexual violence against them is categorized as technology-facilitated gender-based violence in the online to offline world, where services such as transportation are ordered through an online app and result in a person-to-person interaction once the driver picks the passenger up. Since ridesharing drivers are mostly independent contractors, they do not have at their disposal traditional legal and strong organizational remedies to address sexual violence; moreover, like all victims of violence, these methods usually can only be accessed after the incident has taken place.
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