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Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances.
Mol Cell
January 2025
Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. Electronic address:
By building synthetic regulatory landscapes, Jensen et al. and Thomas et al. demonstrate in this issue of Molecular Cell that gene expression levels strongly depend on the genomic distance between enhancers and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.
View Article and Find Full Text PDFElevating the Discourse on the Comorbidity and Treatment of Eating Disorders and Autism Spectrum Disorder: Commentary on Inal-Kaleli et al. and Nimbley et al.
Int J Eat Disord
January 2025
Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Two recent review papers published in the International Journal of Eating Disorders have considerably elevated the rigor of scholarship on the comorbidity between autism spectrum disorder (ASD) and eating disorders. One paper reported that more than one-quarter of individuals with acute anorexia nervosa also have ASD, and that autistic traits are positively correlated with eating disorder psychopathology. The other paper reported that, compared to individuals with low autistic traits, those with high autistic traits report poorer experiences of eating disorder treatment, despite similar treatment outcomes.
View Article and Find Full Text PDFC9orf72 role in myeloid cells: new perspectives in the investigation of the neuro-immune crosstalk in amyotrophic lateral sclerosis and frontotemporal dementia.
Ann Transl Med
December 2024
Department of Neuroscience, Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Jefferson Hospital for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Reply to Pennington, T.E.; Thompson, J.F. Sentinel Node Biopsy in Melanoma Remains a Valuable Clinical Tool. Comment on "Dixon et al. Primary Cutaneous Melanoma-Management in 2024. 2024, , 1607".
J Clin Med
January 2025
Department of Surgery, Formerly of Royal Marsden Hospital, London SW3 6JJ, UK.
We note with interest the commentary by Pennington and Thompson (P&T) regarding our detailed update on the management of primary cutaneous melanoma in 2024 [...
View Article and Find Full Text PDFTotal Hip Replacement or Resistance Training for Severe Hip Osteoarthritis. Reply.
N Engl J Med
January 2025
Bispebjerg Hospital, Copenhagen, Denmark.
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