AI Article Synopsis
- Dengue fever is a significant arboviral disease in tropical regions, with Delhi experiencing several outbreaks, the last one being in 2013.
- The study focuses on the molecular characterization of dengue virus serotype 2 (DENV-2) strains from outbreaks between 2011-2014 in Delhi, revealing three distinct lineages within the Cosmopolitan genotype.
- A novel mutation was found in a 2014 strain, and the research utilized Bayesian methods for analyzing the virus's evolutionary patterns and population dynamics, contributing valuable insights into dengue epidemiology in India.
Article Abstract
Dengue fever is the most important arboviral disease in the tropical and sub-tropical countries of the world. Delhi, the metropolitan capital state of India, has reported many dengue outbreaks, with the last outbreak occurring in 2013. We have recently reported predominance of dengue virus serotype 2 during 2011-2014 in Delhi. In the present study, we report molecular characterization and evolutionary analysis of dengue serotype 2 viruses which were detected in 2011-2014 in Delhi. Envelope genes of 42 DENV-2 strains were sequenced in the study. All DENV-2 strains grouped within the Cosmopolitan genotype and further clustered into three lineages; Lineage I, II and III. Lineage III replaced lineage I during dengue fever outbreak of 2013. Further, a novel mutation Thr404Ile was detected in the stem region of the envelope protein of a single DENV-2 strain in 2014. Nucleotide substitution rate and time to the most recent common ancestor were determined by molecular clock analysis using Bayesian methods. A change in effective population size of Indian DENV-2 viruses was investigated through Bayesian skyline plot. The study will be a vital road map for investigation of epidemiology and evolutionary pattern of dengue viruses in India.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792444 | PMC |
| http://dx.doi.org/10.1371/journal.pntd.0004511 | DOI Listing |
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