The neurogenic link of the CBF regulation provides the "microflow-metabolism-function" coupling by means of external innervation of the brain vessels. According to the principle of regulation through input, the latter can be the level of emotional tension (excitement) and not the current metabolic demands. The neurogenic link cannot be the mechanism of the CBF local self-regulation. The regulation of adequate blood supply of the brain for maintenance of the "function-metabolism-microflow" coupling is carried out by metabolic link of regulatory system.
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Pharmacol Ther
February 2025
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China; State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China. Electronic address:
O-linked β-N-acetylglucosamine (O-GlcNAc) represents a post-translational modification that occurs on serine or threonine residues on various proteins. This conserved modification interacts with vital cellular pathways. Although O-GlcNAc is widely distributed throughout the body, it is particularly enriched in the brain, where most proteins are O-GlcNAcylated.
View Article and Find Full Text PDFMol Psychiatry
November 2024
Department of Pharmacology, School of Medicine, University of Crete, Heraklion, 71003, Greece.
Alzheimer's Disease (AD) is an incurable and debilitating progressive, neurodegenerative disorder which is the leading cause of dementia worldwide. Neuropathologically, AD is characterized by the accumulation of Aβ amyloid plaques in the microenvironment of brain cells and neurovascular walls, chronic neuroinflammation, resulting in neuronal and synaptic loss, myelin and axonal failure, as well as significant reduction in adult hippocampal neurogenesis. The hippocampal formation is particularly vulnerable to this degenerative process, due to early dysfunction of the cholinergic circuit.
View Article and Find Full Text PDFAm J Clin Nutr
January 2025
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore; Departments of Exercise and Nutrition Sciences and Epidemiology, Milken Institute School of Public Health, The George Washington University, Newark, Washington, DC, United States. Electronic address:
Burns
February 2025
Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands; GROW school for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, the Netherlands.
Background: Hypertrophic scars and keloids are forms of pathologic scarring that can give rise to pain and pruritus. The link between nerve function and nerve density and the symptoms in pathologic scars (PS) remains unclear.
Objective: We aim to assess current knowledge on nerve function and nerve density in PS, and to explore a possible association between alterations in sensibility/nerve density and pathologic scar symptoms.
Acta Chir Orthop Traumatol Cech
September 2024
University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Orthopedics and Traumatology, Bakırköy/Istanbul, Turkey.
Heterotopic ossification (HO) denotes aberrant osteogenesis in extra-skeletal tissues, often associated with neurological disorders, total hip arthroplasty, and specific traumatic scenarios. Neurogenic heterotopic ossification manifests prominently subsequent to traumatic brain injury or spinal cord injury, with Guillain-Barre Syndrome presenting an infrequent etiological link. This article details the case of a 56-year-old female diagnosed with Guillain-Barre Syndrome, who developed neurogenic heterotopic ossification around both hips within two years of disease onset.
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