AI Article Synopsis
- Obesity is a significant risk factor for many metabolic disorders like cardiovascular disease and type 2 diabetes.
- Research has highlighted the role of brown and beige fat cells in humans, which help with burning calories and energy expenditure.
- This review will explore the recent discoveries of transcriptional modulators in these fat cells and their potential effects on age-related metabolic issues.
Article Abstract
Obesity represents a major risk factor for the development of a number of metabolic disorders, including cardiovascular disease and type 2 diabetes. Since the discovery that brown and beige fat cells exist in adult humans and contribute to energy expenditure, increasing interest has been devoted to the understanding of the molecular switches turning on calorie utilization. It has been reported that the ability of thermogenic tissues to burn energy declines during aging, possibly contributing to the development of metabolic dysfunction late in life. This review will focus on the recently identified transcriptional modulators of brown and beige cells and will discuss the potential impact of some of these thermogenic factors on age-associated metabolic disorders.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773441 | PMC |
| http://dx.doi.org/10.3389/fendo.2016.00019 | DOI Listing |
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