Assessing next-generation sequencing and 4 bioinformatics tools for detection of Enterovirus D68 and other respiratory viruses in clinical samples.

Diagn Microbiol Infect Dis

Department of Pathology, New York Medical College, Valhalla, NY, USA; Department of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, NY, USA.

Published: May 2016

We used 4 different bioinformatics algorithms to evaluate the application of a metagenomic shot-gun sequencing method in detection of Enterovirus D68 and other respiratory viruses in clinical specimens. Our data supported that next-generation sequencing, combined with improved bioinformatics tools, is practically feasible and useful for clinical diagnosis of viral infections.

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Source
http://dx.doi.org/10.1016/j.diagmicrobio.2016.01.013DOI Listing

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