Morphogenesis is a four-dimensional process which involves the crucial interplay between signaling, mechanical forces, and spatial changes. Caenorhabditis elegans presents a simple yet versatile model to study morphogenesis. Here, we review recent progress on cellular and molecular drivers of morphological changes during C. elegans epiboly and embryonic elongation: actin dynamics and actomyosin contractility, migration guidance cues and junction remodeling. In addition, we discuss how mechanical forces contribute to the process.
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| http://dx.doi.org/10.1016/bs.ctdb.2015.11.012 | DOI Listing |
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