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Spatiotemporal distribution and time-series analysis of rifampicin-resistant tuberculosis in Chongqing municipality, China.
Public Health
March 2025
Department of Epidemiology, School of Public Health, Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. Electronic address:
Objectives: Chongqing has a high burden of rifampicin-resistant tuberculosis (RR-TB), and the implementation of Chongqing's Stop TB Action Plan (2019-2022) as well as the COVID-19 (Coronavirus Disease 2019) pandemic may have affected its distribution. This study aimed to investigate the spatial and temporal distribution characteristics of RR-TB in Chongqing to provide a reference for identifying priority regions for prevention and control.
Study Design: A prospective study.
LINC02363: a potential biomarker for early diagnosis and treatment of sepsis.
BMC Immunol
March 2025
Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Background: Sepsis remains a leading cause of global morbidity and mortality, yet early diagnosis is hindered by the limited specificity and sensitivity of current biomarkers.
Aim: The aim of this study was to identify lncRNAs that play a key role in sepsis and provide potential biomarkers for the diagnosis and treatment of sepsis.
Methods: Transcriptomic data from sepsis patients were retrieved from the Chinese National Genebank (CNGBdb).
Musculoskeletal manifestations in Tuberculosis.
Best Pract Res Clin Rheumatol
March 2025
JSS Academy of Higher Education and Research, Mysuru, Karanataka, India. Electronic address:
Musculoskeletal Tuberculosis (TB) affects the bones, joints and soft tissues and accounts for 1-3 % of TB cases worldwide. The onset of symptoms is usually insidious and nonspecific. It may lead to irreversible joint damage, deformities or neurological manifestations necessitating surgical and rehabilitative corrections due to delayed diagnosis and prolonged latency in the initiation of definitive medical treatment.
View Article and Find Full Text PDFPerformance of Raman Spectroscopy in biopsy tissue for rapid diagnosis of Tracheobronchial Tuberculosis: a prospective study.
Photodiagnosis Photodyn Ther
March 2025
National Center for Respiratory Medicine, Beijing 100029, P.R. China; State Key Laboratory of Respiratory Health and Multimorbidity, Beijing 100029, P.R. China; National Clinical Research Center for Respiratory Diseases, Beijing 100029, P.R. China.; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 100029, P.R. China; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, P.R. China. Electronic address:
Tracheobronchial tuberculosis (TBTB) is a specific form of pulmonary tuberculosis characterized by Mycobacterium tuberculosis involvement in the tracheobronchial tree. Rapid and accurate diagnostic tools for TBTB are crucial. Raman spectroscopy (RS) is a noninvasive tool that accesses molecular vibrations and sample characteristics, enabling the creation of a molecular fingerprint of biological samples, which has enormous potential on clinical diagnosis for TBTB.
View Article and Find Full Text PDFBiologics and Tuberculosis Preventive Therapy.
J Assoc Physicians India
March 2025
Consultant Pulmonologist, Calcutta Medical Research Institute, Kolkata, West Bengal, India, Corresponding Author.
Biologics have revolutionized the management of systemic inflammatory disorders in the last few decades. The most common side effect associated with these agents is increased susceptibility to infection. Increased risk of tuberculosis (TB) reactivation in patients with latent tuberculosis infection (LTBI) has been recorded for anti-tumor necrosis factor (TNF) agents and, to a lesser extent, for the nonanti-TNFα targeted biologics.
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