AI Article Synopsis
- Early embryos can change their cell characteristics easily when exposed to certain inducing factors.
- In later embryo stages, established cell types don't respond to these inducing factors but can change when specific transcription factors are introduced.
- Fully developed cell types are difficult to alter, but using specific combinations of transcription factors shows some promise and could be important for future medical applications.
Article Abstract
The nature of cells in early embryos may be respecified simply by exposure to inducing factors. In later stage embryos, determined cell populations do not respond to inducing factors but may be respecified by other stimuli, especially the introduction of specific transcription factors. Fully differentiated cell types are hard to respecify by any method, but some degree of success can be achieved using selected combinations of transcription factors, and this may have clinical significance in the future.
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| http://dx.doi.org/10.1016/bs.ctdb.2015.11.017 | DOI Listing |
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