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| http://dx.doi.org/10.3324/haematol.2015.141465 | DOI Listing |
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Bio-Engineered Scaffolds Derived from Decellularized Human Esophagus for Functional Organ Reconstruction.
Cells
September 2022
Section of Human Anatomy, Department of Neuroscience, University of Padova, 35121 Padova, Italy.
Esophageal reconstruction through bio-engineered allografts that highly resemble the peculiar properties of the tissue extracellular matrix (ECM) is a prospective strategy to overcome the limitations of current surgical approaches. In this work, human esophagus was decellularized for the first time in the literature by comparing three detergent-enzymatic protocols. After decellularization, residual DNA quantification and histological analyses showed that all protocols efficiently removed cells, DNA (<50 ng/mg of tissue) and muscle fibers, preserving collagen/elastin components.
View Article and Find Full Text PDFEngineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions.
Chem Sci
May 2022
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory Livermore California 94550 USA
Developing chelators that combine high affinity and selectivity for lanthanides and/or actinides is paramount for numerous industries, including rare earths mining, nuclear waste management, and cancer medicine. In particular, achieving selectivity between actinides and lanthanides is notoriously difficult. The protein lanmodulin (LanM) is one of Nature's most selective chelators for trivalent actinides and lanthanides.
View Article and Find Full Text PDFCombined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses.
Acta Biomater
June 2021
Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway; Centre of Molecular Inflammation Research, and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Research Laboratory, Nordland Hospital, Bodo, Norway; Faculty of Health Sciences, K. G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromso, Norway.
Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute significantly to the mechanism of xenograft rejection. We hypothesized that complement component C5 and TLR co-receptor CD14 inhibition would inhibit porcine cornea induced innate immune responses.
View Article and Find Full Text PDFElectroconductive Graphene-Containing Polymeric Patch: A Promising Platform for Future Cardiac Repair.
ACS Biomater Sci Eng
July 2020
Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Myocardial infarction (MI) is one of the leading causes of death worldwide. The complications associated with MI can lead to the formation of nonconductive fibrous scar tissues. Despite the great improvement in electroconductive biomaterials to increase the physiological function of bio-engineered cardiac tissues in vivo, there are still several challenges in creating a suitable scaffold with appropriate mechanical and electrical properties.
View Article and Find Full Text PDFThe REMEDEE trial: 5-Year results on a novel combined sirolimus-eluting and endothelial progenitor cells capturing stent.
Catheter Cardiovasc Interv
May 2020
Cardiovascular Research Foundation, New York, New York.
Objectives: To evaluate the long-term safety and efficacy of the novel combined sirolimus-eluting endothelial progenitor cell capture Combo stent (OrbusNeich, Fort Lauderdale, FL) at 5 years in the REMEDEE (Randomized study to Evaluate the safety and effectiveness of an abluMinal sirolimus coated bio-Engineered stEnt) trial.
Background: Drug-eluting stents have limited restenosis and reintervention but are complicated by late and very late thrombosis and accelerated neoatherosclerosis. Alternative or adjunctive technologies are needed to address these limitations.
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