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Biological Model Development as an Opportunity to Provide Content Auditing for the Foundational Model of Anatomy Ontology. | LitMetric

AI Article Synopsis

  • Constructing a biological model using an established ontology allows for thorough auditing of the ontology's content, particularly in the study of tumor metastasis in head and neck cancer.
  • The research revealed multiple inconsistencies in the lymphatic representations of the Foundational Model of Anatomy (FMA), leading to the identification of errors that could be detected and corrected through computational means and expert review.
  • Overall, 30 new concepts were proposed for addition and 4 for removal regarding organ parts, while 32 concepts were suggested for addition and 15 for removal concerning lymphatic chain instances, enhancing the FMA's accuracy and utility for research and education.

Article Abstract

Constructing a biological model using an established ontology provides a unique opportunity to perform content auditing on the ontology. We built a Markov chain model to study tumor metastasis in the regional lymphatics of patients with head and neck squamous cell carcinoma (HNSCC). The model attempts to determine regions with high likelihood for metastasis, which guides surgeons and radiation oncologists in selecting the boundaries of treatment. To achieve consistent anatomical relationships, the nodes in our model are populated using lymphatic objects extracted from the Foundational Model of Anatomy (FMA) ontology. During this process, we discovered several classes of inconsistencies in the lymphatic representations within the FMA. We were able to use this model building opportunity to audit the entities and connections in this region of interest (ROI). We found five subclasses of errors that are computationally detectable and resolvable, one subclass of errors that is computationally detectable but unresolvable, requiring the assistance of a content expert, and also errors of content, which cannot be detected through computational means. Mathematical descriptions of detectable errors along with expert review were used to discover inconsistencies and suggest concepts for addition and removal. Out of 106 organ and organ parts in the ROI, 8 unique entities were affected, leading to the suggestion of 30 concepts for addition and 4 for removal. Out of 27 lymphatic chain instances, 23 were found to have errors, with a total of 32 concepts suggested for addition and 15 concepts for removal. These content corrections are necessary for the accurate functioning of the FMA and provide benefits for future research and educational uses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765672PMC

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