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Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials.
Neuropsychopharmacology
December 2024
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
This systematic review and network meta-analysis (NMA) sought to compare different antidepressant treatments for treatment-resistant depression (TRD) in order to facilitate evidence-based choices. A literature search of PubMed, Cochrane Library, and Embase from inception until April 13th, 2023 identified randomized, controlled trials (RCTs) of adults with depression who had not responded to at least two antidepressant trials; all RCTs had ≥10 participants per study arm, and participants with bipolar or psychotic depression were excluded. The Cochrane Risk of Bias Tool-2 was used to assess study quality.
View Article and Find Full Text PDFDetection of Crossed Cerebellar Diaschisis in Intractable Epilepsy Using Integrated F-FDG PET/MR Imaging.
Cerebellum
December 2024
Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.
Crossed cerebellar diaschisis(CCD) involves reduced metabolism and blood flow in the cerebellar hemisphere contralateral to a supratentorial lesion. ASL is a valuable tool for quantifying regional cerebral blood flow. This study assesses ASL-MRI's ability to detect CCD in epilepsy using integrated F-FDG PET/MRI and compares ASL with PET images in evaluating CCD.
View Article and Find Full Text PDFConcentric Ring Trajectory Sampling With k-Space Reordering Enables Assessment of Tissue-Specific T and T Relaxation for H-Labeled Substrates in the Human Brain at 7 T.
NMR Biomed
February 2025
High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Deuterium metabolic imaging (DMI) is an emerging Magnetic Resonance technique providing valuable insight into the dynamics of cellular glucose (Glc) metabolism of the human brain in vivo using deuterium-labeled (H) glucose as non-invasive tracer. Reliable concentration estimation of H-Glc and downstream synthesized neurotransmitters glutamate + glutamine (Glx) requires accurate knowledge of relaxation times, but so far tissue-specific T and T relaxation times (e.g.
View Article and Find Full Text PDFSelective PET imaging of CXCR4 using the AlF-labeled antagonist LY2510924.
Eur J Nucl Med Mol Imaging
December 2024
Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Background: [Ga]PentixaFor detects C-X-C chemokine receptor type 4 (CXCR4) overexpression in various malignancies, such as multiple myeloma and non-Hodgkin lymphomas, as well as in endocrine and inflammatory disorders. This study aimed to develop an AlF-labeled radiotracer derived from LY2510924 for CXCR4-targeted imaging, leveraging the physical and logistical advantages of fluorine-18.
Methods: We designed a CXCR4-specific radioprobe, [F]AlF-NOTA-SC, based on LY2510924 by incorporating a triglutamate linker and NOTA chelator to enable AlF-labeling.
Casticin inhibits proliferation of Non-small cell lung cancer cells through regulating reprogramming of glucose metabolism.
Phytomedicine
January 2025
Department of nuclear medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, PR China. Electronic address:
Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with poor prognosis due to its rapid progression and resistance to existing therapies. Metabolic reprogramming, particularly alterations in glucose metabolism, is a key mechanism underlying tumor growth and progression, providing potential targets for novel therapeutic strategies. Casticin (CAS), a bioactive flavonoid, has shown anticancer effects in various cancers, but its specific role in NSCLC metabolism remains unclear.
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