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| http://dx.doi.org/10.4103/0019-5154.174194 | DOI Listing |
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Anti-C1q antibodies in IgG4-related disease are common and associated with renal involvement and cutaneous small-vessel vasculitis.
Rheumatology (Oxford)
January 2025
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Objectives: To evaluate the prevalence and clinical associations of anti-C1q antibodies in IgG4-related disease (IgG4-RD), focusing on renal involvement and cutaneous small-vessel vasculitis (CSVV).
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Effects of Corticosteroid Treatment on Olfactory Dysfunction in LATY136F Knock-In Mice.
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Otolaryngology, Head and Neck Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JPN.
Objective: Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory condition affecting multiple organs, including the pancreas, salivary glands, lungs, kidneys, skin, and lymph nodes. Clinically, it is characterized by elevated serum IgG and IgG4 levels and tissue infiltration by IgG4-positive plasma cells, lymphocytes, fibrosis, and phlebitis obliterans. IgG4-RD is linked to increased Th2-dominant cytokines, contributing to eosinophilia, elevated serum IgG4, and fibrosis.
View Article and Find Full Text PDFIgG4-related disease developing during the course of cutaneous plasmacytosis.
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Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Article Synopsis
- Eosinophilic angiocentric fibrosis (EAF) is a rare, benign condition that typically affects the sinonasal and upper respiratory tract, with very few cases occurring in the brain.
- The report details a case of a 55-year-old man who was initially misdiagnosed with meningioma due to similar clinical and imaging features but was confirmed to have EAF after surgical examination.
- This case highlights the importance of considering EAF in the diagnosis of brain lesions that resemble meningiomas, emphasizing the need for thorough histopathological evaluation for accurate diagnosis and treatment.
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