ARHGEF17 sets the timer for retention of Mps1 at kinetochores.

J Cell Biol

Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210

Published: March 2016

The kinetochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its kinetochore recruitment and activity is unclear. In this issue, Isokane et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201408089) show that interaction with and phosphorylation of its substrate, ARHGEF17, regulates Mps1 kinetochore retention, suggesting an autoregulated, timer-like mechanism.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792080PMC
http://dx.doi.org/10.1083/jcb.201602060DOI Listing

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ARHGEF17 sets the timer for retention of Mps1 at kinetochores.

J Cell Biol

March 2016

Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210

The kinetochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its kinetochore recruitment and activity is unclear. In this issue, Isokane et al. (2016.

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