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| http://dx.doi.org/10.1083/jcb.20141203502192016c | DOI Listing |
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Quantitative Analysis of Kinetochore Protein Levels and Inter-Kinetochore Distances in Mammalian Cells During Mitosis.
Bio Protoc
December 2024
Laboratory of Cellular Dynamics, Regional Centre for Biotechnology, Faridabad, India.
The mammalian kinetochore is a multi-layered protein complex that forms on the centromeric chromatin. The kinetochore serves as the attachment hub for the plus ends of microtubules emanating from the centrosomes during mitosis. For karyokinesis, bipolar kinetochore-microtubule attachment and subsequent microtubule depolymerization lead to the development of inter-kinetochore tension between the sister chromatids.
View Article and Find Full Text PDFA new layer of regulation of chromosomal passenger complex (CPC) translocation in budding yeast.
Mol Biol Cell
September 2023
Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306-4300.
The conserved chromosomal passenger complex (CPC) consists of Ipl1, Sli15, Bir1, and Nbl1, and localizes at the kinetochore/centromere to correct kinetochore attachment errors and to prevent checkpoint silencing. After anaphase entry, the CPC moves from the kinetochore/centromere to the spindle. In budding yeast, CPC subunit Sli15 is phosphorylated by both cyclin-dependent kinase (CDK) and Ipl1 kinase.
View Article and Find Full Text PDFDistinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation.
Mol Biol Cell
May 2023
Department of Biology, Indiana University, Bloomington, IN 47405.
Proper chromosome segregation depends on the establishment of bioriented kinetochore-microtubule attachments, which often requires multiple rounds of release and reattachment. Aurora B and C kinases phosphorylate kinetochore proteins to release tensionless attachments. Multiple pathways recruit Aurora B/C to the centromere and kinetochore.
View Article and Find Full Text PDFDistinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation.
bioRxiv
February 2023
Indiana University, Department of Biology, Bloomington, IN USA.
Proper chromosome segregation depends on establishment of bioriented kinetochore-microtubule attachments, which often requires multiple rounds of release and reattachment. Aurora B and C kinases phosphorylate kinetochore proteins to release tensionless attachments. Multiple pathways recruit Aurora B/C to the centromere and kinetochore.
View Article and Find Full Text PDFDifferential requirement for Bub1 and Bub3 in regulation of meiotic versus mitotic chromosome segregation.
J Cell Biol
April 2020
Department of Biology, Indiana University, Bloomington, IN.
Accurate chromosome segregation depends on the proper attachment of kinetochores to spindle microtubules before anaphase onset. The Ipl1/Aurora B kinase corrects improper attachments by phosphorylating kinetochore components and so releasing aberrant kinetochore-microtubule interactions. The localization of Ipl1 to kinetochores in budding yeast depends upon multiple pathways, including the Bub1-Bub3 pathway.
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