AI Article Synopsis
- The study focused on expressing both normal and mutated forms of the rplC gene in Mycobacterium tuberculosis strains to investigate its role in resistance to oxazolidinones.
- A noticeable increase in the minimum inhibitory concentrations (MICs) of linezolid and sutezolid was observed in the bacteria with the mutated rplC gene (Cys154Arg).
- The findings indicate that the rplC gene plays a significant role in influencing the effectiveness of these antibiotics against the bacteria.
Article Abstract
We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) against the recombinant mycobacteria with overexpressed rplC mutation (Cys154Arg) was found, suggesting the rplC gene is a determinant of bacillary susceptibilities to LZD and PNU.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862453 | PMC |
| http://dx.doi.org/10.1128/AAC.00152-16 | DOI Listing |
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