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Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae. | LitMetric
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Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae.

Aurélie Jayol Patrice Nordmann Marine Desroches Jean-Winoc Decousser Laurent Poirel

Antimicrob Agents Chemother

Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland

Published: May 2016

An extended-spectrum β-lactamase (ESBL)-producing and colistin-resistant Klebsiella pneumoniae clinical isolate was recovered from a patient who was treated with cefotaxime. This isolate harbored a blaCTX-M-15 ESBL gene that was associated with an ISEcp1 insertion sequence. Transposition of that tandem occurred within the chromosomal mgrB gene, leading to inactivation of the mgrB gene and consequently to acquired resistance to colistin. We showed here a coselection of colistin resistance as a result of a broad-spectrum cephalosporin selective pressure.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862518PMC
http://dx.doi.org/10.1128/AAC.00237-16DOI Listing

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