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RAP-2 and CNH-MAP4 Kinase MIG-15 confer resistance in bystander epithelium to cell-fate transformation by excess Ras or Notch activity.
Proc Natl Acad Sci U S A
January 2025
Department of Translational Medical Sciences, School of Medicine, Texas A&M Health Science Center, Texas A&M University, Houston, TX 77030.
Induction of cell fates by growth factors impacts many facets of developmental biology and disease. LIN-3/EGF induces the equipotent vulval precursor cells (VPCs) in to assume the 3˚-3˚-2˚-1˚-2˚-3˚ pattern of cell fates. 1˚ and 2˚ cells become specialized epithelia and undergo stereotyped series of cell divisions to form the vulva.
View Article and Find Full Text PDFStrain redistribution for achieving wide-range and high-sensitivity monitoring of natural rubber-based sensors.
J Colloid Interface Sci
December 2024
Department of Orthopaedic Surgery, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Affiliated Hospital of University of Electronic Science and Technology, Chengdu 610072, China. Electronic address:
Strain sensors with high sensitivity and wide detection range are essential for meeting diverse applications, such as precisely monitoring the movement of patients with bone defects during rehabilitation. However, extending the sensing range without compromising sensitivity, particularly for small strains, remains a significant challenge for flexible sensors. Here, a strain redistribution strategy was employed to achieve wide-range and high-sensitivity monitoring of natural rubber (NR)-based sensors.
View Article and Find Full Text PDFA genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt/β-catenin signaling pathways.
J Am Acad Dermatol
December 2024
deCODE Genetics/Amgen, Inc, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavík, Iceland. Electronic address:
Background: The contributions of genetic and environmental risk factors to hidradenitis suppurativa (HS) are both poorly understood.
Objective: To identify sequence variants that associate with HS and determine the contribution of environmental risk factors and inflammatory diseases to HS pathogenesis.
Methods: A genome-wide association meta-analysis of 4814 HS cases (Denmark: 1977; Iceland: 1266; Finland: 800; UK: 569; and US: 202) and 1.
Hidradenitis Suppurativa from a Multi-Omic Scope.
J Cutan Med Surg
November 2024
Rheumatology Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Article Synopsis
- * Genetic studies have identified issues with Notch signaling and inflammasome function in HS, while syndromic HS is linked to mutations in certain autoinflammatory syndromes like PAPA and PASH.
- * Research in proteomics and microbiome profiling highlights inflammatory pathways and a disturbed balance of bacteria in HS lesions, while metabolomic studies reveal imbalances in tryptophan and lipid metabolism, indicating potential bacterial involvement; however, establishing strong links across these
Acromio-Axillo-Suprasternal Notch Index Performance in Predicting Difficult Visualization of the Larynx: An Observational Prospective Study.
Cureus
August 2024
Anaesthesiology, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Bedside screening tests for predicting difficult intubation play a crucial role in clinical practice, although their utility remains limited. This prospective observational study aimed to assess the predictive value of the Acromio-Axillo-Suprasternal Notch Index (AASI) for difficult visualization of the larynx (DVL). Following approval from the Institutional Ethics Sub-Committee (Research Protocol No.
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