How are cells able to maintain constant levels of mRNA when the number of genes in a cell doubles ahead of cell division?
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798957 | PMC |
| http://dx.doi.org/10.7554/eLife.14953 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice.
Transplant Proc
January 2025
School of Medical Sciences, Emam Reza Hospital Sirjan Faculty of Medical Sciences, Sirjan, Iran.
Background And Aim: Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily involves synovial joints. During the past decade, disease-modifying antirheumatic drugs and biologic agents have been introduced for the treatment of RA. However, they have limitations, including incomplete treatment response, adverse effects requiring drug withdrawal, fall off in efficacy over time, high cost of biologic agents, and refractory cases.
View Article and Find Full Text PDFPunctuational evolution is pervasive in distal site metastatic colonization.
Proc Biol Sci
January 2025
Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
The evolution of metastasis, the spread of cancer to distal sites within the body, represents a lethal stage of cancer progression. Yet, the evolutionary dynamics that shape the emergence of metastatic disease remain unresolved. Here, using single-cell lineage tracing data in combination with phylogenetic statistical methods, we show that the evolutionary trajectory of metastatic disease is littered with bursts of rapid molecular change as new cellular subpopulations appear, a pattern known as punctuational evolution.
View Article and Find Full Text PDFImmune response accelerated telomere shortening during early life stage of a passerine bird, the blue tit ().
Biol Lett
January 2025
Cluster of Biomolecular Science, Division of Toxicology, Wageningen University and Research, 6708 WE Wageningen, The Netherlands.
Dealing with infections is a daily challenge for wild animals. Empirical data show an increase in reactive oxygen species (ROS) production during immune response. This could have consequences on telomere length, the end parts of linear chromosomes, commonly used as proxy for good health and ageing.
View Article and Find Full Text PDF[Estandarización de zimosán opsonizado como estímulo en la técnica de la 1,2,3-dihidrorrodamina para evaluar el estallido respiratorio del neutrófilo].
Biomedica
December 2024
Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatría, Ciudad de México, México.
Unlabelled: Introducción. La enfermedad granulomatosa crónica es un defecto de la fagocitosis por deficiencia de gp91phox, p22phox, p47phox, p40phox y p67phox (forma clásica). Recientemente, se describió la deficiencia de EROS y p40phox como responsables de la forma no clásica.
View Article and Find Full Text PDFModulation of Glutamatergic Burst Activity by Hydrolysed Arabinoxylan Rice Bran: A Multielectrode Array Study in Human-Induced Pluripotent Stem Cell-Derived Neurones and Astrocytes.
Cureus
January 2025
Electrophysiology, 3Brain AG, Genova, ITA.
The natural product MGN-3 (Biobran) is a defatted, partially hydrolysed rice bran-derived hemicellulose enzymatically modified with an extract of . It has a high proportion of arabinoxylan. It has a protective action against intracerebroventricular streptozotocin-induced murine sporadic Alzheimer's disease and reverses spatial memory deficit in this disease model.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!