AI Article Synopsis
- Xanthine oxidase is an important enzyme that converts hypoxanthine and xanthine into uric acid, which can lead to hyperuricemia in humans.
- A study evaluated the xanthine oxidase inhibitory activities of 24 organic extracts from different Citrus species, finding that the ethyl acetate extract of C. aurantium dried immature fruits had the highest activity.
- The research identified and tested several compounds, discovering that hesperetin was particularly effective in inhibiting xanthine oxidase, providing a scientific basis for using C. aurantium in managing hyperuricemia.
Article Abstract
Xanthine oxidase is a key enzyme which can catalyze hypoxanthine and xanthine to uric acid causing hyperuricemia in humans. Xanthine oxidase inhibitory activities of 24 organic extracts of four species belonging to Citrus genus of the family Rutaceae were assayed in vitro. Since the ethyl acetate extract of C. aurantium dried immature fruits showed the highest xanthine oxidase inhibitory activity, chemical evidence for the potent inhibitory activity was clarified on the basis of structure identification of the active constituents. Five flavanones and two polymethoxyflavones were isolated and evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds, hesperetin showed more potent inhibitory activity with an IC50 value of 16.48 μM. For the first time, this study provides a rational basis for the use of C. aurantium dried immature fruits against hyperuricemia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274447 | PMC |
| http://dx.doi.org/10.3390/molecules21030302 | DOI Listing |
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