In the eighties the genes of the T lymphocyte antigen receptor (TcR) have been cloned. The search for the elusive and controversial TcR is over. It is clear that genes for TcR are distinct from those of Ig genes although these genes belong to the immunoglobulin supergene family. The aim of this article is to scan briefly a history of the searching for TcR, than to update our knowledge about TcR. With the search for TcR behind, a new set of question and goals lies ahead. How does TcR, which is similar to Ig, recognize foreign antigen in association with major histocompatibility complex (MHC) gene products? What is the relationship between TcR and Iat molecules, including misterious I-J product?
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