AI Article Synopsis
- The study explored how blood glucose and lipid levels might affect relapse risk in alcohol-dependent men during withdrawal therapy.
- The research involved measuring blood glucose, cholesterol, and triglycerides at different points over six months in 54 patients.
- Results indicated that there were no significant differences in these blood markers between patients who relapsed and those who remained abstinent, although some associations with nicotine addiction were noted.
Article Abstract
Aims: There is evidence for the functioning of feedback between alcohol consumption and fat (positive) and carbohydrate (negative) intake. We tried to verify the hypothesis that blood glucose and lipid concentration in a fasting state and after loading may affect the risk of relapse in alcohol-dependent male patients during withdrawal therapy.
Methods: Blood glucose, total cholesterol (TC) and triglycerides (TG) were determined at the beginning of the study, and again after 4 weeks and 6 months of observation in 54 alcohol-dependent male patients treated against drinking relapse. Glucose concentration was checked after fasting and 2h after loading with a 75 g water solution of glucose, and blood lipids were determined on an empty stomach and 5h after butter loading (0.5 g of butter per kilogram of body mass).
Results: Patients who relapsed compared to subjects who remained abstinent during the 6-month observation did not differ significantly in relation to blood glucose, TC or TG blood concentrations, either in a fasting state or after loading. Patients with an initial above-median increase in TG blood concentration after butter loading (>38%) before the beginning of the study, and who smoked cigarettes with a greater content of nicotine and tar, preferred vodka and had lower values of aminotransferases.
Conclusion: Fasting and postprandial blood glucose, TC and TG concentrations had no relationship with the outcome of anti-relapse treatment. However, they presented some associations with the pathomechanism of addiction to nicotine.
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| http://dx.doi.org/10.1016/j.drugalcdep.2016.02.029 | DOI Listing |
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