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Tailored Bioengineering and Nanomedicine Strategies for Sex-Specific Healing of Chronic Wounds.
Br J Dermatol
November 2024
Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.
Chronic wounds, defined by their prolonged healing process, significantly impair patient quality of life and impose a hefty financial burden on healthcare systems worldwide. Sex/gender-specific mechanisms regulate inflammation and infection, angiogenesis, matrix synthesis, and cell recruitment contribute to cutaneous wound healing, but remain largely understudied. This review is aimed to spotlight the innovative realm of bioengineering and nanomedicine, which is at the helm of revolutionizing complex chronic wound care.
View Article and Find Full Text PDFFrom microscopes to molecules: The evolution of prostate cancer diagnostics.
Cytojournal
August 2024
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
In the ever-evolving landscape of oncology, the battle against prostate cancer (PCa) stands at a transformative juncture, propelled by the integration of molecular diagnostics into traditional cytopathological frameworks. This synthesis not only heralds a new epoch of precision medicine but also significantly enhances our understanding of the disease's genetic intricacies. Our comprehensive review navigates through the latest advancements in molecular biomarkers and their detection technologies, illuminating the potential these innovations hold for the clinical realm.
View Article and Find Full Text PDFFamily planning policy and gender in Nigeria: A thematic analysis of the government's health policy perspective.
Sociol Health Illn
October 2024
Chair of Sociology of Diversity, Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany.
Family Planning (FP) lets people control the number and timing of child-births through using contraceptives and/or restoring fertility. Nigeria has several FP policies for managing its population, yet contraceptives usage remains suboptimal despite high FP awareness, suggesting that several factors might be inhibiting FP uptake. The literature spotlights gender as factoring into FP use due to Nigeria's patriarchal society, with men positioned as gatekeepers to women's sexual/reproductive health/expression.
View Article and Find Full Text PDFImpact of Clinical Factors on F-Flotufolastat Detection Rates in Men With Recurrent Prostate Cancer: Exploratory Analysis of the Phase 3 SPOTLIGHT Study.
Adv Radiat Oncol
August 2024
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
Article Synopsis
- F-Flotufolastat is a newly approved diagnostic imaging drug targeting prostate cancer, evaluated in the SPOTLIGHT clinical trial, which aimed to understand its detection rates based on clinical factors in men suspected of prostate cancer recurrence.* -
- The study involved 389 men and found that detection rates increased significantly with higher baseline prostate-specific antigen (PSA) levels, identifying lesions in 39% of those with prior radical prostatectomy and 43% of those with prior radiation therapy.* -
- Despite varying PSA doubling times and pathologic grades, the detection rates remained consistently high across different patient categories, suggesting effectiveness of F-flotufolastat across a wide range of clinical scenarios.*
Spotlight on necroptosis: Role in pathogenesis and therapeutic potential of intervertebral disc degeneration.
Int Immunopharmacol
September 2024
Lanzhou University Second Hospital, 82 Cuiying Men, Lanzhou 730000, PR China; Orthopedics Key Laboratory of Gansu Province, Lanzhou 730000, PR China. Electronic address:
Intervertebral disc degeneration (IDD) is the leading cause of low back pain, which is one of the major factors leading to disability and severe economic burden. Necroptosis is an important form of programmed cell death (PCD), a highly regulated caspase-independent type of cell death that is regulated by receptor-interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL)-mediated, play a key role in the pathophysiology of various inflammatory, infectious and degenerative diseases. Recent studies have shown that necroptosis plays an important role in the occurrence and development of IDD.
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