The pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG), first described 30 years ago, is a high-molecular neuramino-glycoprotein. Its serum concentration is normally low, but substantially increases during pregnancy and in some malignant tumour diseases. A review is given of occurrence and quantification of alpha 2-PAG under physiological and pathophysiological conditions, site of synthesis and localization, purification and physico-chemical properties, biological role and possible clinical use.
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Article Synopsis
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Department of Orthopedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, PR China; Department of Sports Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, PR China; Fujian Orthopaedics Research Institute, Fuzhou, 350000, PR China; Fujian Orthopedic Bone and Joint Disease and Sports Rehabilitation Clinical Medical Research Center, Fuzhou, 350000, PR China. Electronic address:
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