Benzodiazepines are associated with the risk of developing Alzheimer's disease. Systematic dosage and vitamin D substitution have no place in times of immediate post-menopause. Topical placebos challenge analgesics in the treatment of knee osteoarthritis. Palliative chemotherapy does not improve life-quality at the end of life. Restrictive transfusion thresholds entail no risk. Spirometry should always be performed before the initiation of a long-term bronchodilator therapy. Practitioners continue to overprescribe antibiotics for infections of the upper respiratory tract. Pap test may soon be replaced by HPV urinary testing. Without increasing costs, a telephone triage by the primary care physician can reduce the number of consultations.
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Lung Cancer
January 2025
Dept. of Medical Oncology, Princess Margaret Cancer Center, Toronto, ON, Canada.
Background: Manual extraction of real-world clinical data for research can be time-consuming and prone to error. We assessed the feasibility of using natural language processing (NLP), an AI technique, to automate data extraction for patients with advanced lung cancer (aLC). We assessed the external validity of our NLP-extracted data by comparing our findings to those reported in the literature.
View Article and Find Full Text PDFPLoS One
January 2025
Verana Health, San Francisco, CA, United States of America.
Purpose: To evaluate prevalence and incidence rates of pigmentary maculopathy and retinopathy (PM/PR), and visual acuity (VA) changes in patients exposed to pentosan polysulfate sodium (PPS) and in patients with interstitial cystitis (IC) not exposed to PPS.
Methods: This is a retrospective cohort study (January 2015-March 2021) which included adult de-identified patients from the American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) and Komodo Health database. Three patient cohorts were identified: two PPS-exposed patient cohorts, and Non-PPS-exposed IC patient cohort.
Eur J Cancer Prev
January 2025
Department of Thoracic Surgery.
Leading societies have established guidelines that vary significantly regarding recommendations for the surgical management of pulmonary carcinoids (PC). We aimed to assess current guidelines and recommendations for PC surgical management, benchmark their methodological quality, and identify factors that may influence their effectiveness in guiding surgical practice. Literature was sought to identify relevant guidelines for the management of PC.
View Article and Find Full Text PDFSex Med Rev
December 2024
Digital Human-Environment Interaction Lab, Department of Psychology, Education and Sports, Lusófona University, Inês Tavares, 4000-098 Porto, Portugal.
Introduction: Sexual health concerns are common and significantly impact quality of life, but many people do not seek treatment due to embarrassment and other barriers. A biopsychosocial model of assessment and treatment acknowledges the biological, psychological, and social contributors to sexual difficulties and suggests that all these domains should be evaluated.
Objectives: This paper provides an overview of the major psychological factors contributing to sexual difficulties and offer an evidence-based approach for primary care clinicians to assess and treat these issues.
Background: Studies suggest that structural changes in the midbrain are linked to Alzheimer's disease (AD) symptoms such as memory, sleep, and emotional disturbances. Brainstem atrophy, particularly in the locus coeruleus, has also been linked with poorer executive function. Studies showing brainstem as one of the first regions affected by AD largely employed novel imaging techniques such as neuromelanin-sensitive MRI, which is limited to research environments.
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