Collection of pathological specimens began soon after the seminal description of autopsy by Giovan Battista Morgagni in Padoa in the second half of the 18th Century. Pathologists soon realized difficulties of preserving the form and to prevent decay caused by autolysis and attack by bacteria and parasites. The ancient procedures devoted to mummification were applied to the purpose, and a number of personal experiences were reported in the first half of the 19th century, mainly in Northern Italy and France, testifying a dedicated interest of the time in those areas. A combination of chemical fixation (with corrosive sublimate/mercuric chloride and/or tannic acid) and careful drying allowed to produce dry preparations, once very numerous in the Pathological Anatomy's Museums so much popular in the 19th and early 20th Century. In fact, it was the sole way to give visual evidence of disease and pathological processes. Only a limited number of these dry preparations are still present and visible in Pathology Museums, mainly in Universities of Northern Italy, while a few examples can be traced in the other European Country.
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Am J Respir Cell Mol Biol
January 2025
University of Groningen, University Medical Center Groningen, Department of Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, Netherlands.
Asthma is a genetically complex inflammatory airway disease associated with over 200 Single nucleotide polymorphisms (SNPs). However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples are unknown. Here, we aimed to conduct expression quantitative trait loci (eQTL) analysis using a meta-analysis of nasal and lung samples.
View Article and Find Full Text PDFFood Waterborne Parasitol
March 2025
Unit of Foodborne and Neglected Parasitic Diseases, Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
is a zoonotic nematode parasite of worldwide distribution. It is present in Europe with important foci, particularly in Eastern countries and Spain. This species is generally associated with a domestic cycle that involves primarily pigs.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biological, Geological, and Environmental Sciences, University of Bologna, Bologna, Italy.
The variability of East African short rains (October-December) has profound socioeconomic and environmental impacts on the region, making accurate seasonal rainfall predictions essential. We evaluated the predictability of East African short rains using model ensembles from the multi-system seasonal retrospective forecasts from the Copernicus Climate Change Service (C3S). We assess the prediction skill for 1- to 5-month lead times using forecasts initialized in September for each year from 1993 to 2016.
View Article and Find Full Text PDFJ Infect Dev Ctries
December 2024
SACIDS Africa Centre of Excellence for Infectious Diseases, SACIDS Foundation for One Health, Sokoine University of Agriculture (SUA), P.O. Box 3297 Chuo Kikuu, Morogoro, Tanzania.
Introduction: Peste des petits ruminants (PPR) is an infectious disease that imposes substantial economic burdens on small ruminants (SR) production. For Tanzania to develop efficient management and eradication plans, it is essential to comprehend the seroprevalence of PPR designated for global elimination by 2030.
Methodology: This study investigated the prevalence of PPR in animals kept under pastoral and agropastoral communities in Tanzania.
Front Pharmacol
January 2025
Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Background: Proton pump inhibitors (PPIs) are among the most commonly and inappropriately prescribed drugs by general practitioners (GPs), resulting in increased risk of adverse outcomes for patients and in avoidable costs for Italy's National Health Service (NHS). This study aims to assess the effectiveness of a low-cost and easily implementable informative intervention directed at GPs to enhance the appropriate prescription of PPIs.
Methods: The LAPTOP-PPI study is a pragmatic, cluster-randomized controlled trial designed to improve the appropriateness of PPI prescriptions among community-dwelling individuals aged ≥65 years.
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