AI Article Synopsis
- Nosocomial infections from ESBL-producing E. coli are a significant global health issue that requires urgent attention.
- A gene cluster that includes the Clp ATPase ClpK was identified in Danish isolates, which may enhance bacterial survival.
- This gene cluster provides thermoprotection, allowing the bacteria to withstand higher temperatures often found on medical devices in hospitals.
Article Abstract
Nosocomial infections caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are a major concern worldwide. There is an urgent need to identify bacterial factors promoting survival and persistence of these organisms in the nosocomial environment. Here, we describe the presence of a gene cluster, containing the Clp ATPase ClpK, within a collection of Danish ESBL-producing E. coli isolates. The cluster conferred thermoprotection upon the isolates, and thus might facilitate survival on medical devices exposed to semi-high temperatures in a hospital setting.
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| http://dx.doi.org/10.1016/j.resmic.2016.02.002 | DOI Listing |
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