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Validation and optimization of adiabatic T and T for quantitative imaging of articular cartilage at 3 T. | LitMetric

AI Article Synopsis

  • The study aimed to validate and optimize adiabatic T and T mapping for measuring articular cartilage using a 3 Tesla MRI system.
  • Experiments involved testing different pulse sequences on phantoms and volunteers to determine the best imaging protocol, revealing that relaxation rates varied with agarose and chondroitin sulfate concentrations.
  • Results showed that the developed sequences effectively produced relaxation time maps with good reproducibility, confirming their suitability for in vivo assessment of cartilage at 3 T.

Article Abstract

Purpose: The aim of the present work was to validate and optimize adiabatic T and T mapping for in vivo measurements of articular cartilage at 3 Tesla (T).

Methods: Phantom and in vivo experiments were systematically performed on a 3T clinical system to evaluate the sequences using hyperbolic secant HS1 and HS4 pulses. R and R relaxation rates were studied as a function of agarose and chondroitin sulfate concentration and pulse duration. Optimal in vivo protocol was determined by imaging the articular cartilage of two volunteers and varying the sequence parameters, and successively applied in eight additional subjects. Reproducibility was assessed in phantoms and in vivo.

Results: Relaxation rates depended on agarose and chondroitin sulfate concentration. The sequences were able to generate relaxation time maps with pulse lengths of 8 and 6 ms for HS1 and HS4, respectively. In vivo findings were in good agreement with the phantoms. The implemented adiabatic T and T sequences demonstrated regional variation in relaxation time maps of femorotibial cartilage. Reproducibility in phantoms and in vivo was good to excellent for both adiabatic T and T .

Conclusions: The findings indicate that sequences are suitable for quantitative in vivo assessment of articular cartilage at 3 T. Magn Reson Med 77:1265-1275, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

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Source
http://dx.doi.org/10.1002/mrm.26183DOI Listing

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