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Treating episodic migraine with precision: the evolving landscape of targeted therapies driven by insights in disease biology.
Expert Opin Biol Ther
January 2025
University Medicine Greifswald, Greifswald, Germany.
Introduction: Migraine is a disabling neurological disorder with a complex neurobiology. It appears as a cyclic disorder of sensory processing, affecting multiple systems beyond nociception. Overlapping mechanisms, including dysfunctional processing of sensory input from brain structures are involved in the generation of attacks.
View Article and Find Full Text PDFUnderstanding the Physiopathology of Pain Pathways for a Practical Approach of Cancer Pain Management.
Cardiovasc Intervent Radiol
January 2025
Clinique de la Douleur., Hôpital de La Tour, Geneva, Suisse.
Pain associated with cancer is often the first symptom reported with major repercussions on patient's quality of life. Mechanical compression, release of algogenic substances by the tumor or the complications of oncologic treatment represent the major causes. Nociceptive and neuropathic pain are both induced by different mediators that give rise to a neuroinflammation creating a peripheral and central sensitization responsible of chronic pain.
View Article and Find Full Text PDFA Multimodal Approach to Symptomatic Endometriosis: A Proposed Algorithm for Clinical Management.
Reprod Sci
January 2025
Gynecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Recent research has proven that peripheral (PS) and central sensitization (CS), mental health, and myofascial dysfunction all play a role, alongside nociception, in the genesis and in the perpetuation of endometriosis' symptoms. However, such components of pain are still largely ignored in clinical practice, although not considering such contributors may entail serious consequences on women's health, including the choice of unnecessary surgery and leaving the real causes of pain untreated. At the present time, we are facing a paradox by which 25-40% of women who undergo laparoscopic surgery for pelvic pain do not have an obvious diagnosis, while the percentage of women with endometriosis who have signs of CS, of depressive or anxiety disorders, or who have an increased pelvic muscle tone ammounts to 41-55%, 15-88% and 28-73%, respectively.
View Article and Find Full Text PDFA Survey Study on the Current Veterinary Practice and Attitudes to Anaesthesia and Analgesia for Spay Surgery in the United Kingdom.
Vet Med Sci
January 2025
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Background: In the United Kingdom, spay surgery is routinely performed in dogs and cats by general practitioners. Data from a decade ago showed that, despite an increased attentiveness of veterinarians to peri-operative pain compared to the past, analgesia could be further improved.
Objectives: To investigate the current veterinary practice and attitude towards anaesthesia and analgesia for spay surgery in the United Kingdom.
The Value of Intraoperative Neurophysiological Monitoring During Patient Positioning in Spine Surgery: A Preventive Strategy.
Cureus
November 2024
Neuroanesthesia, Unidade Local de Saúde de Santo António, Porto, PRT.
Article Synopsis
- Cervical spine surgery in myelopathy patients presents anesthetic challenges due to the potential for secondary spinal cord injury (SCI), which requires careful management beyond just intubation concerns.
- Intraoperative neurophysiological monitoring, such as SSEPs and MEPs, is crucial for assessing spinal cord integrity during surgery, especially for patients with conditions like cervical spondylotic myelopathy.
- A case study involving a 73-year-old male with significant cervical deformation underwent successful anterior cervical discectomy and fusion, using advanced monitoring techniques and awake intubation to minimize risks, resulting in a smooth recovery with no new neurological deficits.
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