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Shrill cry, opisthotonus, and sun setting sign in a yellow neonate.
Trop Doct
December 2024
Department of Neonatology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India.
We report a case of severe neonatal hyperbilirubinaemia (NNH) in a term neonate due to rhesus isoimmunisation resulting in classical clinical features of acute bilirubin encephalopathy and its sequel, kernicterus. Though NNH is common, its complications are less often encountered today with the widespread availability of effective phototherapy. It is important not to miss the clinical signs of this preventable cause of neuro-disability.
View Article and Find Full Text PDFReal-world use of the CarestartTM glucose-6-phosphate dehydrogenase rapid diagnostic test to determine G6PD deficiency in Nigerian neonates.
J Trop Pediatr
October 2024
Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55414, United States.
G6PD deficiency (G6PDd) is the most common X-linked genetic disease worldwide and the most common cause of severe neonatal hyperbilirubinemia (NH) in Nigeria. Screening for G6PDd has been recommended for over thirty years but is still not routinely done in Nigeria. We sought to investigate a low-cost rapid diagnostic test to determine G6PDd in Nigerian neonates.
View Article and Find Full Text PDFAssessment of Knowledge and Attitudes of Parents Regarding Neonatal Jaundice in Abia State Children's Specialist Hospital, Umuahia, Nigeria: A Cross-Sectional Study.
Cureus
September 2024
Internal Medicine, Diamed Centre, Lekki, NGA.
Background Neonatal jaundice, characterized by the yellow discoloration of an infant's skin and eyes, is a common condition that affects newborns. It results from an elevated level of bilirubin in the blood and, when severe, if left untreated, can lead to complications such as acute bilirubin encephalopathy and kernicterus, which can cause permanent neurological damage or even death. In low-resource settings like Nigeria, delayed recognition and inadequate management of neonatal jaundice are significant contributors to neonatal morbidity and mortality.
View Article and Find Full Text PDFControversies in our understanding of extreme hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient neonates.
Pediatr Res
October 2024
Department of Neonatology, Shaare Zedek Medical Center (M.K. emeritus), Jerusalem, Israel.
Article Synopsis
- Kernicterus, a preventable condition, is still occurring mainly due to glucose-6-phosphate dehydrogenase (G6PD) deficiency, which is now being seen in places like North America where it was once thought uncommon.
- The paper argues that G6PD deficiency leads to severe hyperbilirubinemia not just because of limited bilirubin processing, but also due to increased red blood cell breakdown (hemolysis).
- Universal screening for G6PD deficiency in newborns could help identify at-risk babies earlier for treatment, potentially preventing severe complications like bilirubin encephalopathy.
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