Mitochondria play important roles in homeostasis of hematopoietic stem cells (HSCs), which exhibit clonal heterogeneity in their lymphoid and myeloid production. Recently in Nature, Luchsinger et al. (2016) showed that mitochondria-ER tethering maintains lymphoid-biased HSCs through calcium-dependent NFAT signaling, providing molecular insights into the basis of HSC heterogeneity.
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| http://dx.doi.org/10.1016/j.stem.2016.02.007 | DOI Listing |
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